SIRT6 and rheumatoid arthritis: For example, the peripheral blood mononuclear cell-derived exosome lncRNA nuclear-enriched abundant transcript 1 (NEAT1) targets and regulates the miR-23a/mouse double minute 2 homolog (MDM2)/sirtuin 6 (SIRT6) axis to promote proliferation and inflammation in RA FLS (Rao et al., 2020).