It is noteworthy that exosomes derived from mesenchymal stem cells have been extensively studied and proven to be beneficial for RA, including: i) Reducing vascular endothelial growth factor (VEGF) expression and angiogenesis: For example, Synovial mesenchymal cell-derived exosomes inhibit miR-485-3p/signal transducer and activator of transcription 3 (STAT3) by transmitting circRNA-circEDIL3 to reduce VEGF expression and angiogenic activity in RA FLS induced in vitro and reduce the extent of arthritis in collagen-induced arthritis (CIA) models (Zhang et al., 2021). This evidence concerns the gene STAT3 and rheumatoid arthritis.