However, when looking at GFAP+ astrocytes by different striatal areas in zQ175 mice compared to WT, the number of GFAP+ astrocytes was significantly increased only in the dm and cm striatum (Figures 1D–F), regions heavily affected in HD (Vonsattel et al., 1985), which accounted for the total increased number observed in the whole striatum analysis. This evidence concerns the gene GFAP and Huntington disease.