TNF and Cognitive impairment: RUNX1 belongs to master regulators for the age-dependent microglia module and increases the level of G9a through histone lysine methylation, leading to the increase of neuroinflammatory markers such as interleukin-6, tumor necrosis factor-α and then cognitive impairment in rats (Grinan-Ferre et al., 2019; Li et al., 2020).