RIG-I recognizes viral RNAs generated during infection with different viruses, including SARS-CoV-2 (Kouwaki et al., 2021; Mao et al., 2022; Marx et al., 2022), IAV (Kato et al., 2006; Rehwinkel et al., 2010), and SeV [35], as well as transfected poly(I:C) (Dauletbaev et al., 2015), being its activation tightly regulated (Brisse and Ly, 2019). The gene discussed is RIGI; the disease is infection.