R language analysis of the TCGA and GEO data exhibited a noticeable elevation of SH2D5 in the LUAD tissues versus normal tissues (Figs. 1C, 1D and 1E) and additional qRT-PCR assay, Western blot and IHC staining displayed consistent results that SH2D5 expressed at a higher mRNA level in mouse LUAD tissues and BEAS-2B and H1299 cell lines as compared to adjacent non-tumor tissues (Fig. 1F, Figs. S2A–S2C). The gene discussed is SH2D5; the disease is neoplasm.