Relative to non-cancerous tissues, SH2D5 expression was elevated in most tumors, such as bladder urothelial carcinoma, cholangiocarcinoma, esophageal carcinoma, head and neck squamous cell carcinoma, renal papillary cell carcinoma, LUAD, lung squamous cell carcinoma, etc. (Fig. 1B). Here, SH2D5 is linked to head and neck squamous cell carcinoma.