PHGDH and cancer: [117] demonstrated a novel link between PHGDH and stemness-maintaining transcription factors POU class 5 homeobox 1, nanog homeobox, SRY-box transcription factor 2, KLF transcription factor 4, and lin-28 homolog B in cancer stem-like cells, such as glioblastoma, lung carcinoma, breast carcinoma, embryonal carcinoma, breast cancer, and brain cancer.