Moreover, tumor-related protein p73 (TRP73), hypoxia-inducible factor (HIF)-1, specificity protein 1, and nuclear transcription factor Y have been reported to induce the expression of PHGDH, PSAT1, and PSPH, which contribute to regulating serine biosynthesis and metabolism in cancer cells [[18], [60],61]. The gene discussed is PSPH; the disease is cancer.