PHGDH and pancreatic ductal adenocarcinoma: [109] found a subset of human pancreatic ductal adenocarcinoma cell lines lacking expression of serine biosynthesis pathway (SBP) enzymes (e.g., PHGDH) that were dependent on exogenous serine for growth and demonstrated that targeting the recruitment of neuronal axons releases amino acids, such as serine, which was able to rescue the growth of exogenous serine–dependent pancreatic ductal adenocarcinoma cells in Ser/Gly-deprived conditions [109].