Recent evidence has shown that the overexpression of PHGDH prevents ubiquitination of the oncogenic transcription factor forkhead box M1 and upregulates the expression of vascular endothelial growth factor (VEGF), matrix metallopeptidase 2, cell cycle checkpoint kinase 2, and cyclin D1, which promotes the proliferation, migration and invasion of glioma cells [98,105]. This evidence concerns the gene VEGFA and central nervous system cancer.