Moreover, the overexpression and interactions of several heat shock proteins (Hsp70, Hsp90, Hsp60, Hsp40, Hsp27) [59–63], PDIs (Erp19, Erp57, TXNDC5, PDIA6, PDI) [64–67], integrins (αvβ5, α5β1, αvβ6, α2β1, α3β1, αvβ3) [68–70], and glycosphingolipid forming multiprotein complexes in the complex tumor microenvironment have been associated with cell malignancy and gastric cancer progression, favoring proliferation, survival, invasion, metastasis, and probably resistance to chemotherapy. The gene discussed is PDIA6; the disease is gastric cancer.