Interestingly, when evaluating the interactions of RV Wt1-5 with tumor-associated immune cells, a significant increase in lymphocytic infiltrate and viral antigens in phagocytic cells at the tumor microenvironment and in the lumen of the blood vessels was observed, suggesting that RV converted non-inflamed tumors into inflamed tumors, allowing activation of the host immune system. The gene discussed is WT1; the disease is neoplasm.