These findings suggest that rotavirus particles can stably interact with Hsp90, Hsp70, Hsp60, Hsp40, Hsc70, PDI, or β3 integrin, using the amino acids that the F(ab`) fragments recognize or nearby areas (specifically of the Hsps) that are overexpressed in the cytoplasmic membrane of gastric tumor cells. This evidence concerns the gene P4HB and gastric neoplasm.