TXNDC5 and neoplasm: Moreover, the overexpression and interactions of several heat shock proteins (Hsp70, Hsp90, Hsp60, Hsp40, Hsp27) [59–63], PDIs (Erp19, Erp57, TXNDC5, PDIA6, PDI) [64–67], integrins (αvβ5, α5β1, αvβ6, α2β1, α3β1, αvβ3) [68–70], and glycosphingolipid forming multiprotein complexes in the complex tumor microenvironment have been associated with cell malignancy and gastric cancer progression, favoring proliferation, survival, invasion, metastasis, and probably resistance to chemotherapy.