AS‐IV prevented glucocorticoid‐induced ANFH by promoting osteogenesis and angiogenesis via the Akt/Runx2 and Akt/HIF‐1α/VEGF pathways, respectively, and suppressing apoptosis and oxidative stress via the Akt/Bad/Bcl‐2 and Akt/Nrf2/HO‐1 pathways, respectively. Here, RUNX2 is linked to familial avascular necrosis of femoral head.