We assessed the role of Akt‐mediated signalling pathways in the ability of AS‐IV to prevent GC‐induced ANFH, which mainly manifests as the promotion of osteogenesis and angiogenesis via the Akt/Runx2 and Akt/HIF‐1α/VEGF pathways, respectively, and as suppression of apoptosis and oxidative stress via the Akt/Bad/Bcl‐2 and Akt/Nrf2/HO‐1 pathways, respectively. The gene discussed is VEGFA; the disease is familial avascular necrosis of femoral head.