Moreover, LY294002 apparently reduced their levels, indicating that the repair response in GC‐induced ANFH might be associated with the Akt/HIF‐1α/VEGF pathway, and failure to repair the necrotic femoral head might be related to the lack of VEGF and HIF‐1α. This evidence concerns the gene AKT1 and familial avascular necrosis of femoral head.