Several isoforms of the CD44 are associated with malignant progression in various tumors [8], including head and neck squamous cell carcinomas (HNSCCs) [9], pancreatic cancers [10,11], breast cancers [12], gliomas [13,14], prostate cancers [15], and colorectal cancers (CRC) [16]. This evidence concerns the gene CD44 and head and neck squamous cell carcinoma.