In NASH and HC samples, the differential expression of KDM6B, KDM4D, JMJD5, JMJD6, JMJD7, and JMJD2A demonstrated statistical significance, and among them, KDM6B, JMJD5, JMJD7, and JMJD2A acting as DEGs. The gene discussed is KDM4D; the disease is metabolic dysfunction-associated steatohepatitis.