Plant homeodomain finger 2 (Phf2 or KDM7C) protected the liver from oxidative stress and fibrogenesis in a mouse model of NAFLD through the demethylation of histone H3 lysine 9 demethylation (H3K9me2) at the promoter of carbohydrate responsive element binding protein (ChREBP) [15]. The gene discussed is PHF2; the disease is metabolic dysfunction-associated steatotic liver disease.