As promising vesicular markers associated with endothelial dysfunction in Type 2 diabetes mellitus (DM2) are the level of CD31+CD144+ EVs, the level of miR-126 in circulating EVs, and an increased ratio of CD31+Annexin V+ EVs to CD31+CD62+ EVs, reflecting the altered immune phenotype of endothelial cell-derived EVs [3,4]. The gene discussed is PECAM1; the disease is diabetes mellitus.