Macrophages, lymphocytes, fibroblasts, keratinocytes, mast cells, dendritic cells, and tumor cells synthesize TNF-α [10], which not only induces inflammation, but also inhibits carcinogenesis by promoting apoptosis, inducing vascular endothelial cell necrosis in tumors, and activating immunocytes and tumor immunity [11,12,13]. This evidence concerns the gene TNF and neoplasm.