The most notable difference was found in the S100A6 biomarker in the SS patient’s tear, the concentration of which was significantly higher in SS patients (513.0 ± 941.7 ng/mL) than in the CTs (45.4 ± 43.9 ng/mL), a 10.31-fold increase (p = 0.0071). The gene discussed is S100A6; the disease is synovial sarcoma.