To the remaining four core variants (rs440446, rs769450, rs429358, and rs7412) are added two variants of unknown biological impact, but investigated in association with plasma lipoprotein traits (rs9282609 and rs877973), as well as three variants in complete linkage disequilibrium: rs61357706-A and rs115299243-G have been associated with an increased risk of cardiovascular ailments, while rs769455-T (also known as “ApoE4 Philadelphia” or “ApoE Qatar”) has been studied in AD and is associated with dyslipidemia. Here, APOE is linked to metabolic syndrome.