The interplay between IL-17 and IL-23, by reducing the number of CD8+ T cells; increasing the activity of Treg cells; and modulating MMP-9, MMP-7, MMP-2, VEGF, TGF-β, IL-6, and CCR6 expression; has a crucial role in the pathogenesis of CRC [10,11,12,13,14]. This evidence concerns the gene IL17A and colorectal carcinoma.