We observed positive correlations between the expression of YKL-40, IL-17A, PD-L1, and MMP-8 (Figure 1) in GEO dataset GDS4382, containing 34 CRC tumors and adjacent non-cancerous tissues (Figure 1A–C,F), and in GEO dataset GDS4515, with 49 CRC microsatellite instable tumors and normal colonic mucosa samples (Figure 1D,E). This evidence concerns the gene CHI3L1 and colorectal carcinoma.