Such findings could be at least partially explained by principles of the recent guidelines for TNM staging (AJCC 8th Edition of Cancer Staging Manual [20]) which incorporate depth of invasion into the clinical staging of oral cavity carcinoma, and we found no significant association between megalin expression and depth of invasion (Table 1), nor between depth of invasion per se and overall survival rate (Table 2). Here, LRP2 is linked to oral cavity carcinoma.