However, when patients were grouped according to certain clinicopathological characteristics, but regardless of the histological grade of the tumor they had had, we found a significantly higher percentage of megalin-positive cells in OSCC tissue of patients with lymph node metastases when diagnosis had been made compared with the tissue of those whose lymph nodes had not been affected at the time of diagnosis (43.05% vs. 23.9%; p = 0.0495) (Table 1, Figure 1). The gene discussed is LRP2; the disease is neoplasm.