TLK2 and neoplasm: Further, thorough the analysis of mRNA-miRNA interaction networks, we found DEGs which were targeted by more miRNAs, including KCND3, SCN1A, NFIA, CYB561D1, TLK2, CDC25A, FAM104A, and HNRNPU. As a member of the nuclear factor I family, NFIA can lead to uncontrolled cell proliferation and tumor initiation and progression and has been reported by Zhao et al. In 2017 in patients with squamous cell cancer, adenocarcinoma and large cell carcinoma41.