The multivariable Cox proportional hazards model adjusted for histologic type, smoking status, tumor size, KRAS mutation status, and EGFR mutation status, as shown in Supplementary Table 4, showed that patients with large tumors (>3.8 cm), a KRAS mutation, and a mixed CD3 + TIM3 + pattern had worse OS than patients with tumors ≤1.5 cm, wild-type KRAS, and an unmixed CD3 + TIM3 + pattern. Here, KRAS is linked to neoplasm.