Among ADC specimens, tumors ≤3.15 cm showed CD3 + CD8 + cytotoxic T-cells, CD3 + CD8 + CD45RO + FOXP3 + cytotoxic memory T-cells, CD3 + CD8negFOXP3 + regulatory T-cells, CD3 + CD45RO + memory regulatory T-cells, B-cells, and LAG3 + B-cells located significantly closer to malignant cells than in the larger tumors (Fig. 5B). Here, CD8A is linked to AIDS dementia complex.