CD274 and AIDS dementia complex: EGFR-mutant tumors had significantly closer distances from CD3 + PD-1+PD-L1 + T-cells to malignant cells and from CD3 + CD8negFOXP3 + regulatory T-cells to CD3 + CD8 + GZB +  activated cytotoxic T-cells than did wild-type tumors in ADC (Fig. 5D).