CD8A and AIDS dementia complex: In contrast, ADC specimens from nonsmokers showed that CD3 + CD8negFOXP3 + regulatory T-cells were relatively close to malignant cells and, most importantly, CD3 + CD8 + cytotoxic T-cells and CD3 + CD45RO + memory T-cells were also close to malignant cells, suggesting a different spatial arrangement and maybe inhibitory mechanism than that observed in tumors from smokers.