Our data also showed that close distances from CD3 + CD8 + cytotoxic T-cells, CD3 + CD8 + GZB + activated cytotoxic T-cells, and macrophages to malignant cells was associated with better OS than long distances in ADC, suggesting that the cell-to-cell proximity of these cells mitigates the suppressive effect of inhibitory cells, and supporting the findings of Barua et al22. The gene discussed is CD8A; the disease is AIDS dementia complex.