CD8A and neoplasm: The Cox proportional hazards regression model adjusted for histologic type, smoking status, tumor size, KRAS mutation status, and EGFR mutation status showed that factors associated with better OS included nonsmoker status, wild-type EGFR, and CD3 + T-cells and CD3 + CD8 + CD45RO + cytotoxic/memory T-cells in an unmixed pattern with close median distances to malignant cells (group 3).