Including T-cell densities, the pattern of distribution, and distances relative to malignant cells in a Cox regression model we identified that densities of cytotoxic T-cells CD3 + CD8 + and distances of activated cytotoxic T-cells CD3 + CD8 + GZB + to malignant cells are important prognostic factors in NSCLC, as previous reports in the literature23,24. The gene discussed is CD8A; the disease is non-small cell lung carcinoma.