TP53 and osteosarcoma: Whole-exome sequencing (WES) analyses of the Fgfr3-p53 cKO bone tumor revealed widespread copy number variations across the genome, including large-scale deletions on chromosomes 8 and 17, as well as large-scale amplifications on chr10, chr11, and chr13 (Fig. 7i), consistent with the widespread genomic instability typically observed in osteosarcoma.