KRT7 and lung cancer: Strikingly, KRT7-AS overexpression markedly enhanced cisplatin-induced apoptosis of lung cancer SPC-A-1 and H1299 cells by more than fivefold (Fig. 4B, D, E), whereas silencing of KRT7-AS in A549 cells significantly decreased cisplatin-induced apoptosis (Fig. 4G, H), suggesting that KRT7-AS enhances cancer cell apoptosis.