CASP3 and lung carcinoma: Mechanically, overexpression of KRT7-AS significantly increased levels of cleaved-caspase 3 and cleaved-PARP in lung cancer cells in the presence of cisplatin (Fig. 5D, E); whereas silencing of KRT7-AS significantly reduced levels of cleaved-caspase 3 and cleaved-PARP in A549 cells (Fig. 5F).