NES and nervous system disorder: Finally, to uncover the potential neurological disorders and traits associated with Pten haploinsufficiency, we curated gene lists by integrating DEPs from the SSC of Pten+/− mice and DEGs from neural cells of Pten+/− and Nes-KO mice by filtering out genes encoding non-DEPs from the DEGs of neural cells as NPC(DEP), AST(DEP), PCN(DEP) and curating translated DEGs comprising DEGs from all neural cells that overlapped with DEPs (Supplementary Table ST3c).