In early life, immediately after the 8 week HF feeding, our results are consistent with the aforementioned reports, demonstrating that the HF diet upregulated Wnt signaling target genes (C-Myc and Cyclin D1) and increased the protein levels of active β-Catenin as well as p-STAT3, an immune response gene that also regulates Wnt signaling target genes [24] (Figure 5A,B). The gene discussed is STAT3; the disease is hydrops fetalis.