The mean LTL ratio (T/S) for HER2-E, HR+, and controls was 1.06 (SD 0.10), 1.22 (SD 0.26), and 0.90 (SD 0.21), respectively, demonstrating statistically significant values between the tumor groups evaluated with the control group (p < 0.0001) (Figure 2A). The gene discussed is ERBB2; the disease is neoplasm.