ERBB2 and neoplasm: Data from the TL evaluation in different subtypes of tumor cell lines revealed that cell lines of the luminal subtype (MCF7) had the greatest TL, followed by HER2-E (SKBR3), and triple-negative cell lines (MDA-MB-231), and also demonstrated that the cell lineages with greater invasiveness had shortened telomeres compared to those with less invasiveness [16].