BRCA1 and cancer: However, these reviews (1) have focused on the efficacy of psychosocial interventions [28,29], (2) have focused on the psychological effects of different risk-management strategies [12,31], (3) have only included cancer-affected BRCA1/2 carriers [30], or (4) have reported men and women or cancer-unaffected and cancer-affected BRCA1/2 pathogenic variant carriers combined [20,26].