Future studies of CSPG4 IgE, and other anti-tumor IgE candidates, may provide an insight into these pathways, the potential roles of different immune cells such as antigen-presenting cells i.e., dendritic cells and B cells, in addition to monocytes/macrophages, and their crosstalk with T cells or NK cells in the tumor microenvironment. This evidence concerns the gene IGHE and neoplasm.