CSPG4 IgE triggered significant levels of antibody-dependent cellular cytotoxicity (ADCC) of A2058 and A375 melanoma cells above isotype control IgE by healthy volunteer and melanoma patient-derived peripheral blood mononuclear cells (PBMCs) (Fig. 3d, left and right, respectively) and human monocytic U937 cells (Fig. 3e). The gene discussed is IGHE; the disease is melanoma.