In healthy volunteer and melanoma patient blood we investigated; IgE titers (n = 38 and n = 13, respectively) and the proportion of monocytes overall within PBMCs (n = 25 and n = 44, respectively) and of monocytes expressing the high-affinity IgE Fc receptor FcɛRI (n = 25 and n = 46, respectively). The gene discussed is IGHE; the disease is melanoma.