The majority of the CD4 T cells in the HT-29 tumor cell killing assay were PD1+IL7R-CD107a+ (Supplementary Fig. 7E), resembling the phenotype of the intratumoral C1-PRF1 CD4 T-cell population identified by scRNAseq (Fig. 5D, E). The gene discussed is CD4; the disease is neoplasm.