This possibility was then further reinforced by publicly available data from a single cell transcriptome in mouse liver reporting that ANGPTL4 in the liver is almost exclusively expressed in the hepatocytes (cells in the liver that are infected by HCV), and by the observation that expression of HCV-3a core in hepatoma cells as well as in mouse liver promotes mRNA expression and secretion of ANGPTL4. This evidence concerns the gene ANGPTL4 and hepatocellular carcinoma.