Studies have reported that Sirtuin 1 plays a protective role in preserving mitochondrial homeostasis in AKI via deacetylating and activating proliferator‐activated receptor‐γ coactivator‐1α (PGC‐1α), a master regulator of mitochondrial biogenesis [31, 33, 34]. Here, PPARGC1A is linked to acute kidney injury.