Our unpublished data are in agreement with those from previous study showing that CAFs express higher basal level of Cyp26b1 when compared to N-MFs isolated from a cancer-free area of colon (Figure 2) High Cyp26b1 expression likely limits the inhibitory effect of atRA on IL-6 expression by reducing atRa levels in stromal cells. This evidence concerns the gene CYP26B1 and cancer.