In a recent study [7], we reported that a profound decrease of alcohol dehydrogenase 1B (ADH1B) occurs in colonic stromal cells (known as fibroblasts or myofibroblasts) during the adenoma-carcinoma sequence and that ADH1B downregulation in CAFs contributes to the disruption of the retinol-mediated suppression of tumor-promoting IL-6 in neoplastic tissue. The gene discussed is IL6; the disease is adenoma.