INS and type 2 diabetes mellitus: The international recommendations for the treatment of T2DM coincide in an individualized strategy according to risk and cardiovascular and/or renal involvement, and among the intensification strategies (additional to oral anti diabetics –OADs–) stand out: basal insulins (BIs), rapid-acting insulins, and GLP-1 receptor agonists (GLP-1RAs) [9-12].