Impaired liver or kidney function, calcitonin ≥50 ng/L> history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, cardiovascular disorders, cerebral stroke, severe uncontrolled treated or untreated hypertension, acute treatment required proliferative retinopathy or maculopathy, history of chronic pancreatitis or idiopathic acute. This evidence concerns the gene CALCA and hypertensive disorder.