Impaired liver or kidney function, calcitonin ≥50 ng/L> history of medullary thyroid carcinoma or multiple endocrine neoplasia type 2, cardiovascular disorders, cerebral stroke, severe uncontrolled treated or untreated hypertension, acute treatment required proliferative retinopathy or maculopathy, history of chronic pancreatitis or idiopathic acute. The gene discussed is CALCA; the disease is multiple endocrine neoplasia type 2.