Identified risk factors for PPBCS include moderate to severe pain (NRS ≥3) at any anatomical site before surgery (OR = 3.60, 95% CI = 1.13–11.44, P = .03), COMT rs6269 GA genotype (OR = 5.03, 95% CI = 1.49–17.04, P = .01) and psychological distress at postoperative day 14 (OR = 1.08, 95% CI = 1.02–1.16, P = .02). The gene discussed is COMT; the disease is Abnormal emotional state.