However, rutin administration exhibits suppression of ACE I activity, activation of ACE II, and down-regulations of B1R and B2R protein expressions in the kidney tissues of IRR-, MT-, and IRR/MT-intoxicated animals; thus, rutin can prevent Ang II accumulation in the kidney tissues that further regulates renal hypertension. The gene discussed is BDKRB2; the disease is renal hypertension.