HSPD1 and Granuloma: Fig. 4G through L show representative images of sybody binding into the biofilms in granulomas. In non-capsulated granulomas, the sybodies could stain the entire lesion (Fig. 4H and K; Video S2). In capsulated granulomas, without permeabilization and blood circulation, we could see the sybodies penetrate under the fibrous capsule and stain the adjacent areas of the biofilm (Fig. 4G and J; Video S1). These results show that we have identified GroEL-targeting sybodies that are not only able to bind biofilms in in vitro cultures but are also able to bind biofilms inside granulomas.