CRH and Anxiety: As gastrointestinal inflammation is highly related to the response of the Hypothalamic Pituitary Adrenal Axis (HPA) to stress, which in turn stimulates the expression of corticotropin-releasing factor (CRF) in the hypothalamus's paraventricular nucleus (PVN) and translated lately to the increase in anxiety-like behaviour (Liu et al. 2011).