Gastric inflammation may alter brain function and affect animal anxiety-like behaviour by increasing proinflammatory cytokines such as (TNF-) (Luo et al. 2013) and through the upregulation of the transcript levels of oxidative stress (HO-1 and Nrf-2) and inflammatory (NF-kB and COX-2 genes) related genes as shown in our results. This evidence concerns the gene PTGS2 and Anxiety.