HMOX1 and Anxiety: They both displayed significant gastroprotective effects, alleviated the Aspirin®-induced anxiety-like behaviour and motor deficits by decreasing the gastric mucosal injury, and improved the stomach architecture by reducing TNF-α-expression in gastric mucosa, inflammatory, and oxidative stress-related genes (NF-KB, HO-1, Nrf-2) while increasing the Keap-1 gene.