We repeated a similar analysis for TOP2A and found that 90% (102) of genes repressed by BAZ2A-TAM in PC3 cells and down-regulated in primary BAZ2Ahigh PCas were also down-regulated in BAZ2Ahigh/TOP2Ahigh tumours compared with BAZ2Alow/TOP2Alow (Figs 6C and D and S3B). This evidence concerns the gene TOP2A and neoplasm.