We found that a large fraction (44%) of these BAZ2A-TAM-regulated genes down-regulated in BAZ2Ahigh/KDM1Ahigh or BAZ2Ahigh/TOP2Ahigh primary PCa were significantly repressed in metastatic PCa compared with normal and primary tumours (44% and 47%, respectively), whereas only few were up-regulated (6% and 8%) (Fig 6G and H). This evidence concerns the gene BAZ2A and posterior cortical atrophy.