However, the analysis of a large cohort of primary PCa and metastatic castration resistant PCa (CRPC) (333 and 118 tumours, respectively) (Cancer Genome Atlas Research Network, 2015; Robinson et al, 2015) revealed a significant positive correlation of both TOP2A and KDM1A levels with BAZ2A expression in both metastatic and primary tumors (Fig 5C–F). Here, TOP2A is linked to posterior cortical atrophy.