In the case of genes up-regulated by BAZ2AΔTAM in PC3 cells, 52% of them were significantly up-regulated by TOP2Ai treatment and included 52 out of the 102 BAZ2A-TAM-repressed genes that were down-regulated in BAZ2Ahigh/TOP2Ahigh primary PCa (Figs 6C and 7H). Here, BAZ2A is linked to posterior cortical atrophy.