SOD1 and amyotrophic lateral sclerosis: Strengthening the early involvement of AIS alterations in ALS pathology, two transcriptomic studies revealed that the AnkG gene transcription was downregulated in whole spinal cord grey matter post-mortem tissues of five patients with sporadic ALS and two patients with familial ALS, including one SOD1 patient with an A4V mutation [107] and in human motor nerves (obtained from diagnostic biopsies) of eight sporadic ALS patients, at a time representing an early phase of the disease [108].