A prime example of the latter is mutations in NKX2.5, which are associated with numerous CHDs, including atrial and ventricular septal defects, and conduction defects, consistent with its requirements in working cardiomyocyte and PC differentiation shown in experimental models (Benson et al., 1999; Ellesøe et al., 2016; Elliott et al., 2003; Jhaveri et al., 2018; McElhinney et al., 2003; Schott et al., 1998; Xie et al., 2013; Yu et al., 2014). This evidence concerns the gene NKX2-5 and Abnormal cardiac septum morphology.