Similar to NKX2.5, NR2F2 mutations in humans have now been associated with myriad CHDs, including atrial septal defects and AVSDs (Al Turki et al., 2014; Nakamura et al., 2011; Poot et al., 2007; Qiao et al., 2018; Upadia et al., 2018). The gene discussed is NKX2-5; the disease is atrial septal defect.