Other mouse models of BH4 deficiency with either reduced pyruvoyltetrahydropterin synthase activity (Pts mutant) or hph‐1 mice also showed alterations in energy metabolism associated with obesity, glucose intolerance and insulin resistance (Korner et al., 2016; Oguri et al., 2017). This evidence concerns the gene PTS and obesity due to melanocortin 4 receptor deficiency.