TP53 and hepatocellular carcinoma: The adducts interact with guanine bases of DNA and cause an arginine to serine mutation at codon 249 of the Tp53 tumor suppressor gene, leading to hepatocarcinogenesis.102,103 There is also a high correlation between HBV, another risk factor for HCC, and aflatoxin B1, as both of these factors are frequent in populations with a high incidence of HCC.