To verify whether the IGF1R/PI3K/AKT pathway mediates the regulation of ESCC lymphangiogenesis by miR‐100‐5p in CAF‐derived exosomes, we detected IGF1R, PI3K, AKT, and p‐AKT expression in TLECs and tumors. Here, IGF1R is linked to esophageal squamous cell carcinoma.