PGR and endometriosis: These findings provide effective evidence for the future production of drugs that can either enhance or inhibit PR function; drugs that can enhance PR function would include drugs that can promote its entry into the nucleus to potentially treat RM and that may have clinical application in other progesterone-related conditions, such as endometriosis, while the development of drugs that can inhibit the function of PR may be useful in breast cancer and endometrial cancer.