In the present study, we further explored the SHP2–ERK–PR signaling pathway, which is differentially expressed in the SHP2 inhibitor RMC-4550-exposed hESCs, RMC-4550-treated pregnant mice and RM tissues, to explore the roles of SHP2 in the regulation of this signaling pathway, to discover the mechanisms underlying the occurrence of miscarriage and decidual dysfunction caused by abortion and SHP2 deficiency and to provide a novel scientific and clinical understanding of the occurrence of miscarriage. Here, PTPN11 is linked to spontaneous abortion.