Altered melanin production, and accumulation or deficiency of melanocytes and melanin, can lead to various dermatoses and oculo-cutaneous pigmentation disorders such as albinism, age-related spots, chloasma, freckles, post-inflammatory hyperpigmentation, melasma, lentigo, malignant melanoma, and oculocutaneous albinism type 1 (OCA1)24,30,.32–39. Here, TYR is linked to freckles.