The long‐chain ceramides were enriched in the blood plasma and skeletal muscle of both mouse models of diabetes and human patients with T2DM and dyslipidaemia.[11] Of the six CerS isoforms, CerS2 demonstrates a preference in the synthesis of long‐chain ceramides.[49] Palmitate treatment of both mouse and human myocytes increased CerS2 expression. This evidence concerns the gene CERS2 and type 2 diabetes mellitus.