Since LMO1 has a central role as a transcriptional cofactor in the adrenergic neuroblastoma CRC (13), the lack of compensation by other lmo family members in zebrafish tumors with low lmo1 expression in MYCN-driven neuroblastomas suggests that neuroblastomas arising in fish with the TATA/TATA and lmo1–/– genotypes employ mechanisms of transformation independent of lmo-family proteins. Here, LMO1 is linked to colorectal carcinoma.