Further analysis of the RNA-Seq data revealed that mesenchymal neuroblastoma CRC transcription factors, including notch2, id1, egr3, irf3, cbfb, bach1a, bach1b, tcf7l2, and mef2b (6), were upregulated in the TATA/TATA tumors compared with GATA/GATA, but not in the lmo1–/– tumors (Figure 5A). Here, IRF3 is linked to neuroblastoma.