ISL1 and colorectal carcinoma: The most prevalent is the adrenergic CRC, including HAND2, GATA3, ISL1, PHOX2B, TBX2, ASCL1, and TFAP2B — which is associated with committed progenitors of the sympathoadrenal cell lineage — while the mesenchymal CRC, including a large number of candidate master transcription factors such as NOTCH2, BACH1, ID1, EGR3, FLI1, CBFB, and STAT3, represents a less differentiated mesenchymal or neural crest-cell–like transcriptional cell state (6–9).