Of note, as in many other acute PD models (e.g., the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine [MPTP] model), α-synuclein–aggregation levels were unaltered (Supplemental Figure 3B), implying that accelerated lipid peroxidation increased the susceptibility of A53T mice to PD. This evidence concerns the gene SNCA and Parkinson disease.