Among the 9 features in the random forest (RF) models, RS was the most important predictor of response, followed by any prior systemic treatment, age, tumor size, IL-8 cytokine levels, and neutrophil-to-lymphocyte ratio (NLR) (Figure 6A), with an overall performance of AUC 0.81 (Figure 6B). This evidence concerns the gene CXCL8 and neoplasm.