In CKD stage, decreased renal phosphorus excretion resulting from increased bone-derived fibroblast growth factor (FGF-23) and renal insufficiency, together with decreased active vitamin D synthesis, stimulates PTH secretion, which eventually manifests as secondary hyperparathyroidism, vitamin D deficiency, hypocalcemia and hyperphosphatemia [2,18]. The gene discussed is FGF23; the disease is Renal insufficiency.