In addition to small-molecule-based treatment, a genetic rescue was also explored based on previous reports of successful Farber and Gaucher disease mitigation by crossing the respective mouse and zebrafish models with an acid sphingomyelinase (SMPD1) deficiency model (Keatinge et al., 2020 preprint; Beckmann et al., 2019). The gene discussed is SMPD1; the disease is Gaucher disease.