Notably, unlike mouse models of Gaucher and Krabbe disease (Tybulewicz et al., 1992; De Gasperi et al., 2004), psap KO zebrafish did not exhibit severe phenotypes until ∼4 mpf, with most fish requiring euthanasia by ∼4.5 mpf owing to difficulty maintaining neutral buoyancy and/or cachexia. The gene discussed is PSAP; the disease is Cachexia.