A detailed examination of OL status in a canine model of fucosidosis identified significant OL loss in the corpus callosum and cerebellar white matter, which stabilized by 16 weeks of age, as visualized by decreased CNP, MAG, MAL and PLP1 expression, and reduced CNP and increased CASP6 staining (Fletcher et al., 2014). Here, CASP6 is linked to fucosidosis.