More than 50 genes associated with DCM have been reported; nevertheless, previous studies have indicated that variants in 17 genes (viz, MYH7, DMD, DSP, VCL, DES, LDB3SCN5A, ACTC1, NEXN, TNNT2, RBM20, PLN, LMNA, TPM1, TNNC1, BAG3 and TTN) constitute the majority of candidate causal and likely candidate causal alterations in DCM.88, 91, 92, 93, 94, 95. The gene discussed is VCL; the disease is familial dilated cardiomyopathy.