Familial hypercholesterolemia (OMIM ID‐143890) is an inherited disease with an autosomal dominant (AD) inheritance mode that is mainly the consequence of defects in three main genes (viz, the LDL receptor [LDLR], apolipoprotein B‐100 [APOB] and proprotein convertase subtilisin/kexin type 9 [PCSK9]). Here, PCSK9 is linked to Alzheimer disease.