CYP3A4 and Alzheimer disease: We found that compared with the normal people, the expressions of GSTA1 and ABCB1 were upregulated, while THRB and EHMT2 were down‐regulated in the temporal cortex (TC) of AD patients; the expressions of NFE2L2 (NRF2) and GSTP1 in the hippocampus (HPC), and RECQL in the frontal cortex (FC) were upregulated, while MAPT was downregulated in the HPC; the expressions of NFE2L2, ALOX15B, CYP3A4, and ABCB1 in the entorhinal cortex (ENT) were upregulated; the expressions of APEX1, THRB, and MAPT were downregulated in the ENT (Figure 5; p < 0.05 and effect size of Cohen's d > 0.8 for all the cases).